IFITM3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11714-1-AP-20UL

Product Code. 16898973

Description

11714-1-AP is a rabbit polyclonal antibody raised against the full-length of human IFITM3.

IFITM3 (interferon induced transmembrane protein 3), also known as 1-8U or IP15, is a multi-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of proteins. IFITM proteins are induced by type I and type II interferons and contain multiple interferon (IFN)-stimulated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellular processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellular processes involving IFITM proteins include cellular anti-proliferative activities and homotypic cell adhesion functions of interferons. In addition, IFITM genes are often upregulated in various cancer cells, suggesting a possible role in carcinogenesis. Localizing to the membrane, IFITM3 is a 133 amino acid protein that is induced by IFN-alpha and IFN-gamma. IFITM3 expression can be regulated by TEF-1, Brg-1 and Sp1.

Specifications

• Antigen: IFITM3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IFITM3
• Gene Alias: 1 8U, Fragilis, IFITM3, IP15
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10410, 361673, 66141
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Immunofluorescence
• Concentration: 0.39 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: P26376, Q01628, Q9CQW9
• Gene Symbols: Ifitm3
• Immunogen: IFITM3 Fusion Protein Ag2285
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat, Human
• Product Type: Antibody
• Isotype: IgG