IDH1 Mouse anti-Human, Monkey, Mouse, Clone:7G8A1, Abnova™

Mouse monoclonal antibody raised against recombinant human IDH1.

Brand:  Abnova MAB17855.100ug

Product Code. 16075136

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq]

Specifications

• Antigen: IDH1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000)
  Flow Cytometry (1:200-400)
  Immunofluorescence (1:50-250)
  Western Blot (1:100-1:500)
  The optimal working dilution should be determined by the end user.
• Gene: IDH1
• Host Species: Mouse
• Quantity: 100 μg
• Target Species: Human, Monkey, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Immunofluorescence, Western Blot
• Clone: 7G8A1
• Description: isocitrate dehydrogenase 1 (NADP+), soluble
• Formulation: In PBS (0.05% sodium azide)
• Gene Alias: IDCD, IDH, IDP, IDPC, PICD
• Immunogen: Recombinant protein corresponding to amino acids 156-298 of human IDH1 from E. coli.
• Gene ID (Entrez): 3417
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid