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Invitrogen™ ICAM3 Recombinant Rabbit Monoclonal Antibody (K01_2M82)
Description
ICAM3 Recombinant Monoclonal Antibody for IHC (P), Western Blot
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
Specifications
Specifications
| Antigen | ICAM3 |
| Applications | Immunohistochemistry (Paraffin), Western Blot |
| Classification | Recombinant Monoclonal |
| Clone | K01_2M82 |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | 50mM tris glycine with 150mM NaCl, 40% glycerol, 0.05% BSA and 0.01% sodium azide; pH 7.4 |
| Gene | ICAM3 |
| Gene Accession No. | P32942 |
| Gene Alias | CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3 |
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Product Title
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