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ICA-121431, MedChemExpress

Product Code. 16463217
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Product Code. 16463217 Supplier Medchem Express Supplier No. HY16787

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Description

MedChemExpress ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM).

ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM).

Specifications

Chemical Name or Material ICA-121431
CAS 313254-51-2
Color Off-White
Purity Grade Notes Research
Molecular Formula C23H19N3O3S2
Quantity 50 mg
Solubility Information DMSO : ≥ 44 mg/mL (97.88 mM)
SMILES O=C(NC1=CC=C(S(NC2=NC=CS2)(=O)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4
Molecular Weight (g/mol) 449.55
Formula Weight 449.55
Percent Purity 98.45%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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