Hydroxychloroquine sulfate, 98%, Thermo Scientific Chemicals

Description

Hydroxychloroquine sulfate, CAS # 747-36-4, is a chemical compound with antiparasitic, antiviral, and anti-rheumatic activities.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Hydroxychloroquine sulfate shows antimalarial activity against malaria parasites mainly in the intra-erythrocytic phase of its life cycle. It acts by inhibiting the heme polymerase inside the food vacuole of the parasites
• It shows an inhibitory activity in autophagy preventing the lysosome fusion with the autophagosome
• Some studies demonstrated that hydroxychloroquine sulfate, due to its antiviral activity can restrict HIV infection in vitro

Applications

• Hydroxychloroquine sulfate displays antiviral and anti-rheumatic activities
• In vitro and in vivo experiments have been performed to investigate the role of hydroxychloroquine sulfate in the treatment of SARS-CoV-2 disease
• Hydroxychloroquine sulfate can be used in immunofluorescence assays to evaluate the antiviral mechanisms in dengue virus-2 infection. In this disease, this compound can activate the innate immune response

Specifications

Chemical Identifiers

• CAS: 747-36-4
• Molecular Formula: C₁₈H₂₆ClN₃O·H₂SO₄
• Molecular Weight (g/mol): 433.96
• MDL Number: MFCD00078203
• InChI Key: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• Synonym: hydroxychloroquine sulfate, hydroxychloroquine sulphate, ercoquin, plaquinol, toremonil, 2-4-7-chloroquinolin-4-yl amino pentyl ethyl amino ethanol sulfate, hydroxychloroquine sulfate usp, plaquenil tn, hydroxychloroquine; sulfuric acid, dsstox_cid_27788
• PubChem CID: 12947
• IUPAC Name: 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid
• SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O

• Melting Point: 240.0°C
• Color: White
• Loss on Drying: 2% max. (105°C, 2 hrs.)
• Infrared Spectrum: Authentic
• Assay Percent Range: 0.98
• Packaging: Glass bottle
• Quantity: 100 g
• Merck Index: 15, 4857
• Solubility Information: Solubility in water: soluble. Other solubilities: practically insoluble in alcohol,chloroform,,ether,acetone and acetic acid
• Formula Weight: 433.96
• Percent Purity: 98%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Hydroxychloroquine sulfate

RUO – Research Use Only