Invitrogen™ HYAL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA593104

Product Code. 16568381

Description

Immunogen sequence: RWAFNWDTKD IYRQRSRALV QAQHPDWPAP QVEAVAQDQF QGAARAWMAG TLQLGRALRP RGLWGFYGFP DCYNYDFLSP NYTGQCPSGI RAQNDQLGWL WGQSRALYPS IYMPAVLEGT GKSQMYVQHR VAEAFRVAVA AGDPNLPVLP YVQIFYDTTN HFLPLDELEH SLGESAAQGA AGVVLWVSWE NTRTKESCQA IKEYMDTTLG PFILNVTSGA LLCSQALCSG HGRCVRRTSH PKALLLLNPA SFSIQLTPGG GPLSLRGALS LEDQAQMAVE FKCRCYPGWQ APWCERKSMW; Positive Samples: Mouse liver, Mouse lung; Cellular Location: Lysosome.

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: HYAL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HYAL1
• Gene Alias: Hya1; HYAL1; Hyal-1; Hyaluronidase; hyaluronidase 1; hyaluronidase-1; hyaluronoglucosaminidase 1; hyaluronoglucosaminidase-1; LUCA1; LuCa-1; Lung carcinoma protein 1; MPS9; NAT6; plasma hyaluronidase; tumor suppressor LUCA-1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15586, 3373, 367166
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q12794, Q76HN1, Q91ZJ9
• Gene Symbols: HYAL1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 136-435 of human HYAL1 (NP_1493492).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG