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Proteintech™ HumanKine™ Recombinant Human R-Spondin-I Protein

Product Code. 17711499 Shop All Proteintech Products
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17711499 10 μg 10µg
17701499 100 μg 100µg
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Product Code. 17711499 Supplier Proteintech™ Supplier No. HZ132810UG

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Description

R-Spondin 1 plays several roles in embryonic development including sex phenotype reversal, female sex determination, and ovarian differentiation.

R-Spondin 1 is an approximately 40kDA, glycosylated protein that serves as a major agonist of the Wnt signaling pathway. It regulates the turnover of the LRP6 co-receptor by preventing its internalization by DKK-1. It also promotes stem cell turnover in the mammary glands, intestine, colon, and kidneys. Increased R-Spondin 1 expression has been linked to growth and migration of ovarian cancer cells as well as decreased sensitivity of gliomas to radiation-based therapies (PMID: 17804805, 22439850, 32749219, 30572097).

Specifications

Gene ID (Entrez) 284654
Quantity 10 μg
Source Human
Endotoxin Concentration <1 EU/μg
Specific Reactivity Human
Mass 40 kDa
Form Lyophilized
Purity or Quality Grade >95%
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