Proteintech HumanKine™ recombinant human IL-5 protein

Product Code. 17660097

Brand: Proteintech HZ132410UG

Description

HumanKine™ recombinant protein

IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity (PMID: 21986312, 22174445, 19819937, 16895557)

Specifications

• Accession Number: P05113
• Formulation: 1 x PBS
• Gene ID (Entrez): 3567
• Molecular Weight (g/mol): 35-38 kDa
• Quantity: 10 μg
• Source: HEK293
• Storage Requirements: Lyophilized product should be stored at -20°C to -80°C until expiry date and (at Room Temperature for 2 weeks.)
• Endotoxin Concentration: <0.1 EU/μg
• Specific Reactivity: Human
• Recombinant: Recombinant
• Reconstitution: Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1 xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
• Activity: 0.2-0.9 ng/mL EC50
• Form: Lyophilized
• Purity or Quality Grade: >95%