Invitrogen™ VEGF Receptor 3/FLT4 Human ELISA Kit
For the quantitative detection of human VEGF-R3/FLT-4.
Brand: Invitrogen™ BMS2064TEN
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionThe main function of the lymphatic system is to return plasma back to the circulating blood. Plasma fluid, macromolecules and cells, such as leucocytes and activated antigen-presenting cells, enter the blind-ended lymphatic vessels. Lymph is then transported toward collecting lymphatic vessels and is returned to the blood circulation. Scientific studies over the past years have revealed a signal-transduction system for lymphatic endothelial cell growth, migration and survival. This system is formed by VEGF-C and VEGF-D and their shared receptor VEGFR-3/FLT-4. Homozygous deletion of VEGFR-3 in mice leads to defects in blood-vessel remodelling and embryonic death at mid-gestation, indicating an early vascular function for the receptor. Furthermore mouse studies suggest that upregulation and activation of VEGFR-3 have functional roles in sprouting angiogenesis and that VEGFR-3 is an important effector of the vascular phenotype resulting from Notch inhibition. In lymphoma patients, high expression of VEGFR-3 can been found in lymph endothelial cells isolated from the tumour tissue.
|Plasma, 20 μL|Serum, 20 μL|Supernatant, 20 μL|
|1 hr. 20 min.|
|FLT-4, VEGF receptor 3, PCL|
|Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers|
|50 μL (1:10 prediluted)|
|2°C to 8°C|
|3 hr. 30 min.|
|10 x 96 Tests|
|Colorimetric Microplate Reader|
For Research Use Only