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Invitrogen™ Human UGGT1 (aa 871-996) Control Fragment Recombinant Protein

Product Code. 30208302
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30208302

Brand: Invitrogen™ RP90247

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This item is not returnable. View return policy

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-52981 (PA5-52981. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides. UGGT catalyzes the transfer of glucose from UDP-glucose to Man7-9GlcNAc2-moiety of unfolded glycoproteins in a Ca2+ dependent reaction. UGGT binds unfolded glycoprotein via two elements on its substrate: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids that are exposed in the denatured conformation. It is postulated that UGGT serves as a sensor that is able to distinguish between folded and denatured protein in the ER.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9NYU2
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 56886
Name Human UGGT1 (aa 871-996) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias 0910001L17Rik; A930007H10Rik; AA589501; AI414429; AI448372; C820010P03Rik; Gt; HUGT1; RUGT; rUGT1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose glycoprotein glucosyltransferase 1; UDP-glucose glycoprotein: glucosyltransferase UGGT; UDP-glucose:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1; UGCGL1; Uggt; Uggt1; Ugt1; Ugtr
Common Name UGGT1
Gene Symbol Uggt1
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence DFILSHAVYCRDVLKLKKGQRAVISNGRIIGPLEDSELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGDPRIEYQFFEDRHSAIKLRPKEGETYFDVVAVVDPV
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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