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Invitrogen™ Human TNPO2 (aa 331-363) Control Fragment Recombinant Protein

Product Code. 30211185
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30211185

Brand: Invitrogen™ RP107820

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This item is not returnable. View return policy

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-67176 (PA5-67176. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O14787
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 30000
Name Human TNPO2 (aa 331-363) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias 1110034O24Rik; AA414969; AI464345; AI852433; importin 3; IPO3; karyopherin (importin) beta 2 b; karyopherin beta 2 b, transportin; karyopherin beta-2 b; Knpb2b; Kpnb2b; TNPO2; transportin 2; transportin 2 (importin 3, karyopherin beta 2 b); transportin-2; TRN2
Common Name TNPO2
Gene Symbol TNPO2
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence QDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDD
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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