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Invitrogen™ TGF beta-1 Human ELISA Kit

For the quantitative detection of human TGF-beta1.

Brand:  Invitrogen™ BMS249-4TEN

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15581827

  • £2250.00 / Pack of 10


Estimated Shipment
03-11-2020
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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human TGF-beta1
Biotin-Conjugate anti-human TGF-beta1 monoclonal antibody
Streptavidin-HRP
Human TGF-beta1 Standard lyophilized, 4ng/mL upon reconstitution
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Adhesive Films

Description

Description

TGF beta-1 (TGFB1,Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines,found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain,which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1,an amino-terminal portion of the TGF-beta precursor,designated TGF-LAP (TGF-latency associated peptide),and a specific binding protein,known as LTBP. TGF beta-1 helps regulates proliferation,differentiation,adhesion,migration in many cell types. Many cells have TGF beta receptors,and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide,and is found in either a latent form composed of a TGFB1 homodimer,a LAP homodimer,and a latent TGFB1-binding protein,or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells,and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
Specifications

Specifications

P01137
ELISA
ELISA Kit
8.6pg/mL
Plasma, 20 μL|Serum, 20 μL|Supernatant, 20 μL
1 hr. 20 min.
Human
Camurati-Engelmann disease, DPD1
3.2%
Human
HRP
31-2,000pg/mL
7040
RUO
40 μL (pretreated)
2°C to 8°C
4 hr. 30 min.
TGFB1
4.9%
10 x 96 Tests
Supernatant
Colorimetric Microplate Reader
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