Gibco™ Human TFF-3 Recombinant Protein, PeproTech®

Product Code. 17812303

Brand: Gibco™ 300615UG

Description

Recombinant Protein

Recombinant Human TFF-3 is a 13.2 kDa homodimeric protein consisting of two 59 amino acid chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. Trefoil peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain and clustered in human chromosome 21q22.3. Trefoil Factor 3 (TFF3) is one of three trefoil peptides secreted by epithelial cells that line mucus membranes in the large and small intestines and lower respiratory tract. TFF3 is mainly active as a disulfide-linked homodimer and may have a role in promoting cell migration in healing processes. It is involved in the maintenance and repair of the intestinal mucosa.

Specifications

• Accession Number: Q07654
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 7033
• Molecular Weight (g/mol): 13.2 kDa
• Name: Human TFF-3
• Quantity: 5 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: hITF; hP1.B; Intestinal trefoil factor; ITF; mITF; P1B; Polypeptide P1.B; rITF; rP1.B; Tff3; TFI; Trefoil factor 3; trefoil factor 3 (intestinal); trefoil factor 3, intestinal
• Common Name: TFF3
• Gene Symbol: TFF3
• Biological Activity: Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 ug/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.