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eBioscience™ Human IL-28, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand:  Affymetrix eBioscience 34-8363-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15568796

  • £415.15 / 100µg


Estimated Shipment date
from Supplier 30-06-2017
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Specifications

Description

IL-28A belongs to the IFN lambda family, a novel family of cytokines within the IL-10 superfamily. The three members of this family are IL-29 (IFN lambda 1), IL-28A (IFN lambda 2), and IL-28B (IFN lambda 3), and are also known as the type III Interferons.

The IFN lambdas signal through a heterodimeric receptor of which one subunit, IL-10R2, is shared with other members of the superfamily. The second subunit, IFN lambda R1 or IL-28R alpha, is unique to the IFN lambdas. Signaling occurs through the Jak/STAT pathway in a similar manner as the type I IFN (IFN alpha/beta) and activates many of the same genes despite low sequence homology between the cytokines and receptors in the two families. Both IFN families display antiviral activity through the induction of antiviral protein production in target cells and the upregulation of MHC class I expression. These proteins also exhibit antiproliferative and antitumor effects, making them a possible alternative to IFN alpha cancer therapies. Unlike the type I IFN, which are able to stimulate most cells, response to IFN lambda stimulation appears to be limited to dendritic and some tumor cells due to the limited expression of IFN lambda R1. Another notable difference is the ability of the IFN lambda stimulation to drive dendritic cells towards the production of CD4+CD25+FoxP3+ regulatory T cells, suggesting a possible immunoregulatory role
Description & Specifications

Specifications

Functional Assays
19.6kDa
SDS-PAGE and HPLC
100μg
Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier protein (e.g., 0.1% BSA) at less than or equal to -20°C.
E. coli (amino acids Pro27-Val200; Accession # NP_742150)
Interleukin-28A, Interferon lambda 2
Recombinant Protein, Carrier-Free
Human
Lyophilized from 10mM acetic acid
IL-28
>98%
E. coli
RUO
Less than 0.1ng/μg cytokine as determined by the LAL assay
The ED50 of this protein, as measured by activation of STAT phosphorylation in human colon carcinoma cells, is 0.3-0.5ng/mL.
Unlabeled
Yes