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STEMCELL Technologies Human Recombinant TNF-alpha
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Quantity:
10 μg
50 μg
Unit Size:
10µg
50µg
Description
- Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways
- Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions
- Many other cell types have been shown to produce TNF-α, among them B cells, NK cells, mast cells, neutrophils, dendritic cells, microglia, endothelial cells, smooth muscle cells, cardiomyocytes, and fibroblasts
- TNF-α has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immuno- suppressive responses
- TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová & Hosek)
- Other effects of TNF-α include vasodilatation and edema formation
Specifications
Specifications
| Name | Cachectin, Cachexin, Cytotoxin, DIF, Necrosin, TNF, TNF-α, TNFSF2, Tumor necrosis factor-α |
| Quantity | 50 μg |
| Cell Type | Airway Cells; B Cells; Hematopoietic Stem and Progenitor Cells; Intestinal Cells; Neurons; NK Cells |
| Purity or Quality Grade | ≥95% |
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