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STEMCELL Technologies Human Recombinant IL-7

Product Code. 17139451
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Product Code. 17139451

Brand: STEMCELL Technologies 78053

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Description

Interleukin 7

  • Interleukin 7 (IL-7) is a member of the Type I cytokine family that is critical for T and B cell development and survival
  • It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.) IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways
  • IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh)
  • Although a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT-5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige)

Specifications

Name Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor
Quantity 100 μg
Cell Type Hematopoietic Stem and Progenitor Cells; Lymphocytes
Purity or Quality Grade ≥95%
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