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STEMCELL Technologies Human Recombinant IL-12

Product Code. 17109391
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Quantity:
1000 μg
25 μg
5 μg
Unit Size:
1000µg
25µg
5µg
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Product Code. 17109391

Brand: STEMCELL Technologies 78027.2

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This item is not returnable. View return policy

Description

Interleukin 12

  • Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits
  • IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils, and B cells in response to bacterial products and cytokines such as IFN-γ
  • The IL-12 receptor is expressed on T, NK, and dendritic cells
  • Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford et al.) It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann & Rüde)
  • Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation, and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford et al.)

Specifications

Quantity 1000 μg
Cell Type B Cells; Hematopoietic Stem and Progenitor Cells; Lymphocytes; NK Cells; T Cells
Purity or Quality Grade ≥95%
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