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STEMCELL Technologies Human Recombinant IL-11

Product Code. 17119381
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Product Code. 17119381

Brand: STEMCELL Technologies 78025

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Description

Interleukin 11

  • Interleukin 11 (IL-11) is a pleiotropic cytokine with effects on various tissues including the bone marrow, brain, and intestinal mucosa
  • It belongs to the IL-6 family of cytokines that share a common signal transducer, gp130
  • IL-11 induces the proliferation of hematopoietic stem cells and megakaryocytic progenitor cells, the maturation of megakaryocytes, and the production of platelets
  • IL-11 is produced by a variety of cell types including hematopoietic cells, mesenchymal cells, epithelial cells, and neuronal cells
  • It was first cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102
  • The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases
  • IL-11 was the first pharmacologic agent approved for the treatment of chemotherapy-induced thrombocytopenia

Specifications

Name Adipogenic inhibitory factor, AGIF, Interleukin-11, Oprelvekin
Quantity 100 μg
Cell Type B Cells; Hematopoietic Stem and Progenitor Cells; Other; Pluripotent Stem Cells; T Cells
Purity or Quality Grade ≥95%
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