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STEMCELL Technologies Human Recombinant HBEGF

Product Code. 17129731
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Quantity:
10 μg
50 μg
Unit Size:
10µg
50µg
This item is not returnable. View return policy

Product Code. 17129731

Brand: STEMCELL Technologies 78163

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This item is not returnable. View return policy

Description

Heparin-binding EGF-like growth factor

  • Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi & Klagsbrun)
  • HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto & Mekada)
  • It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi & Klagsburn)
  • HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick et al.) It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto & Mekada)
  • HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes
  • HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata et al.)

Specifications

Name Diphtheria toxin receptor, DTR, HBEGF, Heparin binding EGF-like growth factor
Quantity 10 μg
Cell Type Fibroblasts; Keratinocytes; Smooth Muscle; T Cells, CD4+
Purity or Quality Grade ≥95%
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