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STEMCELL Technologies Human Recombinant GDNF

Product Code. 17109471
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Product Code. 17109471 Supplier STEMCELL Technologies Supplier No. 78058.3

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Description

Glial cell line-derived neurotrophic factor

  • Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor and a member of the tumor growth factor (TGF)-beta superfamily
  • The GDNF family of growth factors also includes neurturin, persephin, and artemin, which have seven conserved cysteine residues called cysteine-knots
  • GDNF family ligands signal through binding to specific GDNF-family receptor-α (GFRα) co-receptors and activate the RET receptor tyrosine kinase
  • Four different forms of GFRα co-receptors have been characterized (GFRα 1-4); GDNF binds specifically to GFRα1 prior to forming a complex with RET (Airaksinen & Saarma)
  • GDNF, together with Human Recombinant BDNF (Catalog #78005), BrainPhys™ Neuronal Medium (Catalog #05790), and other supplements, can be used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons

Specifications

Name Astrocyte-derived trophic factor, ATF, ATF1, ATF2, Glial cell-derived neurotrophic factor
Quantity 500 μg
Cell Type Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Neurons
Purity or Quality Grade ≥95%
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