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STEMCELL Technologies Human Recombinant BMPR-1A Fc

Product Code. 17169851
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1000 μg
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500 μg
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100µg
20µg
500µg
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Product Code. 17169851

Brand: STEMCELL Technologies 78212.3

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Description

Bone morphogenetic protein receptor type 1A, Fc tag

  • Bone morphogenetic protein receptor type 1A (BMPR-1A) is a type I receptor of the BMP receptor family of transmembrane serine/threonine kinases (Abe; Fischerauer et al.; it is also known as ALK3
  • BMPR-1A is a receptor for BMP-2, BMP-4, GDF-5, and GDF-6
  • Binding of BMPs to receptor complexes results in phosphorylation of intracellular SMADs, which go on to regulate transcription (Pan et al.) BMP regulation plays a role in proliferation, differentiation, migration, and apoptosis of endothelial and vascular smooth muscle cells (Abe)
  • BMPR-1A deficiency is lethal during gastrulation (Mishina et al.) BMPR-1A is important in chondrogenesis and osteogenesis, along with BMPR-1B (Fischerauer et al.; Jing et al.) This protein contains a C-terminus linker (IEGRMD) to an Fc tag (Human IgG1)

Specifications

Name Activin receptor-like kinase 3, ACVRLK3, ALK3, BMP type-1A receptor, BRK‐1, CD292, Serine/threonine-protein kinase receptor R5, SKR5
Quantity 1000 μg
Cell Type Chondrocytes; Endoderm, PSC-Derived; Endothelial Cells; Mesenchymal Stem and Progenitor Cells; Mesoderm, PSC-Derived; Osteoblasts; Pluripotent Stem Cells; Smooth Muscle
Purity or Quality Grade ≥95%
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