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STEMCELL Technologies Human Recombinant BAFF

Product Code. 17109321
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Quantity:
10 μg
1000 μg
50 μg
Unit Size:
1000µg
10µg
50µg
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Product Code. 17109321

Brand: STEMCELL Technologies 78002.2

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This item is not returnable. View return policy

Description

B cell activating factor

  • B cell activating factor (BAFF) is part of the tumor necrosis factor (TNF) superfamily and is expressed by monocytes, macrophages, dendritic cells, and neutrophils (Mackay & Browning; Scapini et al.) It binds to 3 receptors: BAFF-R, TACI, and BCMA, all of which are expressed by B cells at various times in their development (Liu & Davidson)
  • BAFF-R signaling activates the NF-kB signaling pathway, and promotes B cell survival, Ig class switching, and antigen presentation (Bossen & Schneider; Liu & Davidson; Naradikian et al.) BAFF also has functions in other cell types: it promotes monocyte survival and activation, proinflammatory cytokine secretion, and differentiation into macrophages (Chang et al.), and co-stimulates anti-CD3-mediated activation of human T cells (Huard et al.; Mackay & Leung)

Specifications

Name BLyS, TALL1, TNFSF13B
Quantity 1000 μg
Cell Type B Cells
Purity or Quality Grade >95%
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