Invitrogen™ Human PTPRCAP (aa 112-169) Control Fragment Recombinant Protein

Product Code. 30207202

Brand: Invitrogen™ RP100004

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (33%), Rat (33%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-60487 (PA5-60487. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1 can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress. Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain.

Specifications

• Accession Number: Q14761
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 5790
• Name: Human PTPRCAP (aa 112-169) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: AI605264; CD45 associated protein; CD-45-AP; CD45-AP; CD45-associated protein; LPAP; LSM-1; Lymphocyte phosphatase-associated phosphoprotein; protein tyrosine phosphatase receptor type C-associated protein; protein tyrosine phosphatase, receptor type C associated protein; protein tyrosine phosphatase, receptor type, C polypeptide-associated protein; protein tyrosine phosphatase, receptor type, C-associated protein; Ptprcap; PTPRC-associated protein
• Common Name: PTPRCAP
• Gene Symbol: PTPRCAP
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: DTDYDHVADGGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLVLGSPGPASA
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining