Invitrogen™ Human POLG2 (aa 1-94) Control Fragment Recombinant Protein

Product Code. 30198669

Brand: Invitrogen™ RP109904

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (37%), Rat (37%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-145191 (PA5-145191. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.

Specifications

• Accession Number: Q9UHN1
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 11232
• Name: Human POLG2 (aa 1-94) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: AA409516; DNA polymerase gamma; DNA polymerase gamma 2, accessory subunit; DNA polymerase gamma accessory 55 kDa subunit; DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha); DNA polymerase gamma, catalytic subunit; DNA polymerase subunit gamma-1; DNA polymerase subunit gamma-2, mitochondrial; DNA-directed DNA polymerase gamma; HP55; MDP1; Mip1; MIRAS; Mitochondrial DNA polymerase accessory subunit; mitochondrial DNA polymerase catalytic subunit; mitochondrial DNA polymerase gamma; mitochondrial DNA polymerase gamma catalytic subunit; mitochondrial DNA polymerase subunit gamma-2; mitochondrial DNA polymerase, accessory subunit; mitochondrial DNA polymerase-gamma; mitochondrial polymerase gamma; mitochondrial polymerase gamma 2; MTDPS4A; MTDPS4B; MTPOLB; p55; PEO; PEOA4; Pol gamma; POLB; POLG; POLG1; Polg2; POLGA; PolG-alpha; POLGB; polG-beta; polymerase (DNA directed), gamma; polymerase (DNA directed), gamma 2, accessory subunit; polymerase (DNA) gamma 2, accessory subunit; polymerase (DNA) gamma, catalytic subunit; polymerase, gamma; polymerase, gamma 2; SANDO; SCAE; truncated mitochondrial DNA polymerase gamma catalytic subunit
• Common Name: POLG2
• Gene Symbol: POLG2
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSG
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining