Human PAR2 Mouse anti-Human, Clone: SAM11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9699-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15587606

Quantity Price
1 £ 149.04 / 100µg
EU Stock 5
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Description and Specification

Specification

Isotype IgG2a
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Enzyme Linked Immunosorbent Assay
Applications Functional Assay
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Quantity 100μg
Conjugate Unlabeled
Storage Requirements Store at 2-8°C.
Concentration 0.5mg/mL
Host Species Mouse
Antigen Human PAR2
Format Purified
Clone SAM11
Primary or Secondary Primary
Species Reactivity Human
Regulatory Status RUO

The monoclonal antibody SAM11 recognizes human PAR2 (Protease activated receptor 2). PAR2 is a member of the PAR family which is a sub-family of the G protein coupled receptors (GPCR). Unlike most of the GPCR family members, PARs are not activated through ligand binding, but through proteolytic cleavage of the amino terminus. PAR2 activation is induced by trypsin, mast cell tryptase, neutrophil proteinase 3, tissue factor-factor VIIa-factor Xa, human kallikrein-related peptidases and membrane-tethered serine proteinase-1/matriptase-1. Unlike other PARs, PAR2 is not activated by thrombin. PAR2 is widely expressed in many tissues, including skin, liver, kidney, small intestine, and colon. PAR2 plays a key role in numerous inflammatory diseases and cancers. The SAM11 antibody has been reported to inhibit the ability of serine proteinases to activate PAR2.