Abnova™ Human PAK4 kinase domain (O96013, 300 a.a. - 591 a.a.) Partial Recombinant Protein

Product Code. 16131850

Brand: Abnova™ P5384.10ug

Description

Used for Func, SDS-PAGE

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Accession Number: O96013
• Concentration: 1 mg/ml
• For Use With (Application): Functional Study, SDS-PAGE
• Formulation: Liquid
• Gene ID (Entrez): 10298
• Molecular Weight (g/mol): 33.3kDa
• Name: PAK4 (Human) Recombinant Protein
• Preparation Method: Escherichia coli expression system
• Quality Control Testing: Loading 7 ug protein in SDS-PAGE
• Quantity: 10 μg
• Immunogen: GPHMSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT The first 4 residues GPHM are from Turbo3C Protease cleavage site. The underlined S is phosphorylated S474.
• Storage Requirements: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Regulatory Status: RUO
• Common Name: PAK4
• Gene Symbol: PAK4
• Biological Activity: Specific activity: 5,595pmoles/min/μg
• Species: E. coli
• Recombinant: Recombinant
• Protein Tag: None
• Expression System: Escherichia coli expression system
• Form: Liquid