Invitrogen™ Human ORMDL1 (aa 72-99) Control Fragment Recombinant Protein

Product Code. 30195480

Brand: Invitrogen™ RP105362

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (96%), Rat (96%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66786 (PA5-66786. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in -gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD). Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.

Specifications

• Accession Number: Q9P0S3
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 94101
• Name: Human ORMDL1 (aa 72-99) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: Adoplin-1; C730042F17Rik; HSPC202; ORM1-like 1; ORM1-like 1 (S. cerevisiae); ORM1-like protein 1; ORMDL sphingolipid biosynthesis regulator 1; ORMDL1
• Common Name: ORMDL1
• Gene Symbol: ORMDL1
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: FETPDQGKARLLTHWEQLDYGVQFTSSR
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining