Gibco™ Human OAT3 (G) SLC Transporter Cells

HEK293 cells that transiently overexpress the OAT3 solute carrier (SLC) transport protein

Brand:  Gibco™ GM1104G

Product Code. 17196622

Description

• TRANSiPORT Human OAT3 (G) SLC Transporter Cells are HEK293 cells that transiently overexpress the OAT3 solute carrier (SLC) transport protein. Solute carriers are a super-family of membrane transporters that can affect pharmacokinetics and drug exposure by governing the transport of solutes in and out of cells. The OAT3 SLC transporter protein is found in kidney proximal tubule, choroid plexus, and brain endothelial cells.
• Assess potential for transporter-mediated drug metabolism
• Easy to use format
• Obtain high quality results with a large signal-to-noise ratio
• Can be performed using radioisotope-labeled compounds, fluorescence-labeled compounds, or non-labeled compounds. The amount of substrate transported into the cells can be measured directly using a liquid scintillation counter, fluorescence plate reader, or LC-MS/MS, thereby allowing direct evaluation of SLC transporter activity.
• Mock HEK293 cells (Cat. No. GM1101G) that do not overexpress the SLC transporter are available for use as a negative experimental control. Some compounds may demonstrate high background levels of transport due to the presence of endogenous transporters or non-specific binding.

Specifications

• Content And Storage: Store in liquid nitrogen vapor phase.
• Culture Type: Mammalian Cell Culture
• No. of Cells: 8-10 x 10⁶ cells

• Cell Line: 293 (HEK)
• Species: Human
• Product Type: SLC Transporter Cell