Invitrogen™ Human Nkx6.1 (aa 63-107) Control Fragment Recombinant Protein

Product Code. 30182423

Brand: Invitrogen™ RP97603

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (96%), Rat (96%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57809 (PA5-57809. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

NKX6.1 is a bi-functional transcription factor that has effects in both the central nervous system and in the pancreas. It has both expression and repression effects on genes, leading to the proper formation of motoneurons, oligodendrocytes, and insulin-secreting beta cells. It is known to interact with Pax6 and Pdx-1, probably at or near the 60 amino acid homeobox DNA-binding domain. Due to its obvious relationship to beta cells and CNS, NKX6.1 is becoming a more interesting target for therapies in diabetes and certain brain diseases.

Specifications

• Accession Number: P78426
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 4825
• Name: Human Nkx6.1 (aa 63-107) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: Drosophila NK transcription factor related, gene family 6, locus 1; homeobox protein NK-6 homolog A; Homeobox protein Nkx-6.1; homeodomain transcription factor Nk x 6.1; NK homeo box, family 6, member A; NK homeobox, family 6, A; NK6 homeobox 1; NK6 transcription factor homolog A; NK6 transcription factor related locus 1; NK6 transcription factor related, locus 1; Nk x 6.1; Nk x 61; NK x 6-1; Nk x 6 A
• Common Name: Nkx6.1
• Gene Symbol: NKX6-1
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: PLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSM
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining