Invitrogen™ Human NKG2C (aa 206-229) Control Fragment Recombinant Protein

Product Code. 30213330

Brand: Invitrogen™ RP105632

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (38%), Rat (38%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66127 (PA5-66127. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.

Specifications

• Accession Number: P26717
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 3822
• Name: Human NKG2C (aa 206-229) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: CD159 antigen-like family member C; CD159A; CD159c; cd159e; killer cell lectin like receptor C2; killer cell lectin-like receptor subfamily C, member 2; KLRC1; KLRC2; NK cell receptor C; NKG2; NKG2A; NKG2C; NKG2-C; NKG2-C type II integral membrane protein; NKG2-C-activating NK receptor
• Common Name: NKG2C
• Gene Symbol: KLRC2
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: CAVLQVNRLKSAQCGSSMIYHCKH
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining