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Gibco™ Human Neurturin Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Brand:  Gibco™ 450-11-1MG

Additional Details : Weight : 0.16500kg

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Product Code. 17834723

  • £2410.00 / 1mg
Estimated Shipment: 12-08-2024
to see stock.

Description

Description

Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFR-b, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR-a-2 recently. NTN binds to and forms a complex with GFR-a-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.
Specifications

Specifications

Q99748
protein with no preservative
23.6
2 x 500 μg
-20°C
<1 EU/μg
NRTN
Unconjugated
ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV
≥ 98% by SDS-PAGE gel and HPLC analyses.
ELISA, Functional Assay, Western Blot
4902
Human Neurturin
E. coli
RUO
neurturin; NRTN; NTN; prepro-neurturin
Human
Recombinant
Lyophilized
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