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ACROBiosystems Human Nectin-2 / CD112 Protein, His Tag

Product Code. 15877567
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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15877567 100 μg 100µg
15887567 1 mg 1mg
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Product Code. 15877567 Supplier ACROBiosystems Supplier No. PV2H52E2100UG

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Description

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.4 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number NP_002847.1
Molecular Weight (g/mol) 37.4 kDa
Quantity 100 μg
Source Human Nectin-2, His Tag (PV2-H52E2) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Leu 360 (Accession # Q92692-2).
Immunogen Gln 32 - Leu 360
Storage Requirements -20°C
Gene Alias CD112,Nectin-2,PVRL2
Common Name Nectin-2
Conjugate Unconjugated
Species Human
Protein Tag His Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Immune Checkpoint Proteins
Purity or Quality Grade >95% as determined by SDS-PAGE
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