Gibco™ Human/Mouse/Rat BDNF Recombinant Protein, PeproTech®

Artikelnummer.	Quantity	unitSize
17874463	100 μg	100µg
17834733	10 μg	10µg
17824183	1 mg	1mg
17894313	250 μg	250µg
17854143	2 μg	2µg
17854253	500 μg	500µg
17874523	50 μg	50µg

Artikelnummer. 17874463 missing translation for 'mfr' Gibco™ missing translation for 'supplierNo' 45002100UG

Beschreibung

Recombinant Protein

Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.

Spezifikation

• Accession Number: P21237, P23363, P23560
• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Gene ID (Entrez): 12064, 24225, 627
• Molecular Weight (g/mol): 27 kDa
• Name: Human/Mouse/Rat BDNF
• Quantity: 100 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
• Common Name: BDNF
• Gene Symbol: BDNF
• Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.