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Invitrogen™ Human MMP-13 Recombinant Protein

Product Code. 11529081
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Quantity:
10 μg
Unit Size:
10µg
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Product Code. 11529081

Brand: Invitrogen™ RP77530

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Description

Recombinant Protein

MMP13 Recombinant Protein, RP-77530, from Invitrogen.

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type. RP-77530 is a purified recombinant MMP-13 protein, expressed in Sf9-insect cells using the baculovirus expression vector system. This protein contains the 452 amino acids of full-length Procollagenase-3, with a C-terminal His-tag. Upon incubation with APMA, active collagenase-3 is formed. RP-77530 may be used as a control with corresponding anti-MMP-13 antibodies. Specific Activity: The specific activity of collagenase-3 is >200 mU/mg, with 1 U defined as the activity that hydrolyzes 1 umol peptide within 1 minute in an enzyme assay.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P45452
For Use With (Application) Control
Formulation TBS with 0.05% Brij-35, 5mM CaCl2 and no preservative; pH 7.5
Gene ID (Entrez) 4322
Name Human MMP13
pH Range 7.5
Quantity 10 μg
Source Insect Cells
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias Procollagenase 3
Common Name Human MMP13
Gene Symbol MMP13
Specific Reactivity Human
Conjugate Unconjugated
Cross Reactivity Hu
Species Baculovirus
Recombinant Recombinant
Form Liquid
Protein Subtype Recombinant
Purity or Quality Grade purified
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in vitro research only.

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