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Invitrogen™ Human MIOS (aa 743-862) Control Fragment Recombinant Protein

Product Code. 30213431
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30213431

Brand: Invitrogen™ RP106384

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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (98%), Rat (98%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-65713 (PA5-65713. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9NXC5
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 54468
Name Human MIOS (aa 743-862) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias C81488; FLJ20323; GATOR complex protein MIOS; H_DJ1159O04.1; meiosis regulator for oocyte development; MIO; Mios; Missing oocyte meiosis regulator homolog; missing oocyte, meiosis regulator, homolog; missing oocyte, meiosis regulator, homolog (Drosophila); RGD1308432; Sea4; WD repeat-containing protein mio; WUGSC:H_DJ1159O04.1
Common Name MIOS
Gene Symbol MIOS
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence SISYSCSAVPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLINMGTPVSSCPGGTKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTCKCMQLD
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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