Invitrogen™ Human MFSD2A (aa 217-252) Control Fragment Recombinant Protein

Product Code. 30181065

Brand: Invitrogen™ RP99818

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (56%), Rat (56%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-60242 (PA5-60242. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.

Specifications

• Accession Number: Q8NA29
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 84879
• Name: Human MFSD2A (aa 217-252) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: 1700018O18Rik; HMFN0656; major facilitator superfamily domain containing 2; major facilitator superfamily domain containing 2 A; major facilitator superfamily domain-containing protein 2 A; MCPH15; MFSD2; MFSD2A; NLS1; PP9177; RGD1310174; sodium-dependent LPC symporter 1; sodium-dependent lysophosphatidylcholine symporter 1; UNQ300/PRO341; zgc:101615
• Common Name: MFSD2A
• Gene Symbol: MFSD2A
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: IVGQADTPCFQDLNSSTVASQSANHTHGTTSHRETQ
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining