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Invitrogen™ Mer (MERTK) Human ELISA Kit

Sandwich ELISA Kit

Brand:  Invitrogen™ EHMER

Code : NEW

Additional Details : Weight : 0.33000kg

Product Code. 15475063

  • £438.00 / 1 set


Estimated Shipment date
from Supplier 15-06-2020
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Description

Description

MERTK is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Specifications

Specifications

Q12866
HRP
0.15ng/mL to 40ng/mL
ELISA, Protein Assays, Protein Biology, Cancer Biology, Immunology, Neuroscience, Neurobiology, Protein Detection, Protein Analysis
Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
RUO
100 μL per sample after dilution
This ELISA kit shows no cross-reactivity with the following cytokines tested: ANGPTL3, beta IG-H3, CA9, Cathepsin B, CD23, CHI3L1, CTLA-4 (CD152), DKK-4, DPPIV (CD26), EDA-A2, Erythropoietin R, FGF-6, FGF-9, Gas 1, GITR (TNFRSF18), IGFBP-5, IL-1 F5 (FIL1 delta), IL-1 F6 (FIL1 epsilon), IL-1 F7 (FIL1 zeta), IL-1 F8 (FIL1 eta), IL-1 F9 (IL-1 H1), IL-1 F10 (IL-1HY2), IL-1 R5, IL-21 (IL-17C), IL-18, IL-20, IL-34, IL-5 R alpha, IL-10 R alpha, Layilin, Leptin R, Marapsin, MMP-7, P-Cadherin, Prostasin, PSMA (FOLH1), SIGIRR, TGF beta R3, Coagulation Factor III (Tissue Factor, F3), TWEAK (TNFSF12)
96 assays
4 hr. 45 min.
Solid-phase sandwich ELISA
Apoptosis
MER, RP38, Tyro12, c-Eyk, c-mer
<10%
Human
Colorimetric Microplate Reader
0.164-40 ng/mL
Biotin
10461
ELISA Kit
0.15 ng/mL
Plasma, 50 μL|Serum, 50 μL|Supernatant, 100 μL
2°C to 8°C
1 hr. 20 min.
Human
Kinase & Inhibitors
MERTK
<12%
96 Tests
Supernatant
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