Invitrogen™ Human MARCKSL1 (aa 86-181) Control Fragment Recombinant Protein

Product Code. 30198423

Brand: Invitrogen™ RP102571

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (92%), Rat (92%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56495 (PA5-56495. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

MARCKS (Myristoylated alanine-rich protein kinase C substrate), also designated 80K or 80K-L, is a 332 amino acid protein that localizes to the plasma membrane and functions as a major cellular substrate for protein kinase C (PKC). MARCKSL1 (MARCKS-like protein 1), also known as MacMARCKS, MLP, MRP, or F52, is a 195 amino acid protein that, like MARCKS, is a major substrate for PKC. Expressed in a variety of tissues with highest levels found in testis and uterus, MARCKSL1 participates in the coordination of membrane-cytoskeletal signaling events, including secretion, migration, phagocytosis and cell adhesion. Additionally, MARCKSL1 functions as a regulator of Integrin activation and is thought to regulate Integrin-dependent signal transduction pathways, especially those involved in macrophage spreading.

Specifications

• Accession Number: P49006
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 65108
• Name: Human MARCKSL1 (aa 86-181) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: AL022768; AW215397; AW536807; brain protein F52; D4Bc1; F52; MACMARCKS; Mac-MARCKS; Macrophage myristoylated alanine-rich C kinase substrate; Macs2; Macs3; MARCKS like 1; Marcksl1; MARCKS-like 1; MARCKS-like protein 1; MARCKS-related protein; MLP; MLP1; Mrp; myristoylated alanine-rich C kinase substrate
• Common Name: MARCKSL1
• Gene Symbol: Marcksl1
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: PKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGKAAATPESQEPQAKGAEASAASEEEAGPQATEPSTPSG
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining