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Invitrogen™ Human MAN1B1 (aa 563-650) Control Fragment Recombinant Protein

Product Code. 30202688
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30202688

Brand: Invitrogen™ RP101484

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This item is not returnable. View return policy

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (84%), Rat (84%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62428 (PA5-62428. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544]. Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699]. Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9UKM7
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 11253
Name Human MAN1B1 (aa 563-650) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias 3.2.1.113; E430019H13Rik; endoplasmic Reticulum Class I alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1; ER alpha 1,2-mannosidase; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; ERManI; Gm108; MAN1B1; Man9GlcNAc2-specific processing alpha-mannosidase; man9GlcNAc2-specific-processing alpha-mannosidase; MANA-ER; Mannosidase alpha class 1 B member 1; mannosidase, alpha, class 1 B, member 1; MRT15; RGD1563595; RP11-350O14.2; UNQ747/PRO1477
Common Name MAN1B1
Gene Symbol MAN1B1
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence METGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKP
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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