Invitrogen™ Human Kallikrein 6 His-tag Recombinant Protein

Product Code.	Quantity	unitSize
17956461	50 μg	50µg

Product Code. 17956461 Supplier Invitrogen™ Supplier No. RP88091

Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (200 μL) be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV.

Kallikreins, including Kallikrein 6, are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK6 enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease.

Specifications

• Accession Number: Q92876
• Concentration: 0.25 mg/mL
• For Use With (Application): Control, Bioactivity
• Format: Lyophilized
• Formulation: PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
• Gene ID (Entrez): 5653
• Molecular Weight (g/mol): 10,25 kDa
• Name: Human Kallikrein 6 His-tag
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 50 μg
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Endotoxin Concentration: <1.0 EU/μg
• Gene Alias: 0610007D04Rik; AI849898; brain serine protease; BSP; Bssp; Glandular kallikrein K1; hK6; Kal; KAL-B; kallikrein 1; kallikrein 29; kallikrein 6; kallikrein 6 (neurosin); kallikrein 6 (neurosin, zyme); kallikrein 7; kallikrein related peptidase 6; kallikrein related-peptidase 6; kallikrein renal/pancreas/salivary; kallikrein-1; Kallikrein6; Kallikrein-6; Klk1; Klk1b6; Klk29; Klk6; Klk-6; Klk7; MGC9355; mGK-6; MSP; myelencephalon-specific protease; myofibril-bound protease; neurosin; Protease M; protease serine 9 (neurosin); protease, serine, 18; protease, serine, 9; PRSS18; PRSS9; renal kallikrein; Serine protease 18; serine protease 9; SP59; tissue kallikrein-6; true tissue kallikrein; zyme
• Common Name: Kallikrein 6
• Gene Symbol: Klk6
• Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate Boc-QARAMC. The specific activity is > 25 pmols/min/ μg. (Activation description: The proenzyme needs to be activated by Lysyl-Endopeptidase for an activated form)
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Human KLK6 isoform 1, amino acids Met1-Lys244 (Accession # Q92876-1) with a C-terminal His-tag
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Activity: Measured by its ability to cleave the fluorogenic peptide substrate Boc-QARAMC. The specific activity is > 25 pmols/min/ μg. (Activation description: The proenzyme needs to be activated by Lysyl-Endopeptidase for an activated form)
• Expression System: HEK293 cells
• Form: Lyophilized
• Purity or Quality Grade: ≥95% as determined by SDS-PAGE.