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Invitrogen™ Human IQSEC1 (aa 399-479) Control Fragment Recombinant Protein

Product Code. 30196457
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30196457

Brand: Invitrogen™ RP96356

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This item is not returnable. View return policy

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58268 (PA5-58268. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain. As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q6DN90
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 9922
Name Human IQSEC1 (aa 399-479) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARFGEP100; ARF-GEP100; AW561907; BC026481; BRAG2; brefeldin A-resistant ARF-GEF2; brefeldin-resistant Arf-GEF 2 protein; cI-43; D6Ertd349e; GEP100; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; Iqsec1; Kiaa0763
Common Name IQSEC1
Gene Symbol IQSEC1
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence GSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNS
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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