Gibco™ Human IL-4 Receptor alpha (soluble) Recombinant Protein, PeproTech®

Product Code. 17830413

Brand: Gibco™ 20004R15UG

Description

HEK293 cells Recombinant Protein

IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.

Specifications

• Accession Number: P24394
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 3566
• Molecular Weight (g/mol): 23.9
• Name: Human IL-4 Receptor alpha (soluble)
• Quantity: 15 μg
• Source: HEK293 cells
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: 582J2.1; CD124; il-4 receptor; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4-binding protein; IL4-BP; Il4r; IL4R nirs variant 1; IL-4 R subunit alpha; IL4RA; IL-4 RA; IL-4 R-alpha; interleukin 4 receptor; interleukin 4 receptor, alpha; interleukin-4 receptor alpha chain; interleukin-4 receptor subunit alpha; Soluble IL-4 receptor subunit alpha; Soluble interleukin-4 receptor subunit alpha
• Gene Symbol: IL4R
• Specific Reactivity: Human
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.