Gibco™ Human IL-36 alpha (IL-1F6) Recombinant Protein, PeproTech®

Product Code. 17861723

Brand: Gibco™ 20036A100UG

Description

Recombinant Protein

200-36A-1MG will be provided as 2 x 500 μg (200-36A-500UG). Recombinant Human IL-36alpha is a 17.2 kDa protein containing 154 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36alpha (IL-1F6), beta (IL-1F8), and gamma (IL-1F9). IL-36alpha is highly expressed in psoriatic plaques, as are IL-36beta and IL-36gamma, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells. Primarily found in skin and lymphoid tissues, IL-36alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3.

Specifications

• Accession Number: Q9UHA7
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 27179
• Molecular Weight (g/mol): 17.2 kDa
• Name: Human IL-36 alpha (IL-1F6)
• Quantity: 100 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: FIL1; FIL1 epsilon; FIL1(EPSILON); Fil1e; Fil1epsilon; IL-1 epsilon; IL1(EPSILON); Il1e; Il1f6; IL-1F6; IL-1F6 (FIL-1-epsilon); Il1f9; Il1h1; IL-1H1; IL1RP2; Il36a; Interleukin; interleukin 1; interleukin 1 family, member 6; interleukin 1 family, member 6 (epsilon); interleukin 1 family, member 9; interleukin 1, epsilon; interleukin 36, alpha; interleukin-1 epsilon; Interleukin-1 family member 6; interleukin-1 homolog 1; Interleukin-36; Interleukin-36 alpha
• Common Name: IL1F6
• Gene Symbol: IL36A
• Biological Activity: Measured by its ability to induce IL-8 secretion by A431 human epidermoid carcinoma cells.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MKIDTPQQGS IQDINHRVWV LQDQTLIAVP RKDRMSPVTI ALISCRHVET LEKDRGNPIY LGLNGLNLCL MCAKVGDQPT LQLKEKDIMD LYNQPEPVKS FLFYHSQSGR NSTFESVAFP GWFIAVSSEG GCPLILTQEL GKANTTDFGL TMLF
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.