Invitrogen™ Human IL-29 (IFN lambda-1), AOF Recombinant Protein

Product Code. 17686525

Brand: Invitrogen™ RP87708

Description

E. coli Recombinant Protein

IFN-lambdas constitute a novel family of interferons that mediate the induction of anti-viral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known as IL-29, IL-28A, and IL-28B, respectively. Similar to type I IFNs, IFN-lambdas activate an intracellular signaling to promote gene expression. IFN-lambdas mediate their anti-viral protection through a class II cytokine receptor complex composed of two essential receptor proteins, CRF2-12/IFN-lambdaR1, which is unique to IFN-lambdas, and CFR2-4/IL-10R2, which is shared with IL-10, IL-22, and IL-26 receptors. The IFN-lambdas, IL-28 and IL-29, have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. DCs that differentiate in response to IFN-lambdas express high levels of class I and II MHC gene products, but low levels of costimulatory molecules. Moreover, these cells can specifically induce IL-2-dependent proliferation of CD4+CD25+FOXP3+ T cells with contact-dependent suppressive activity.

• Purity: >95% by SDS-Page
• Endotoxin Concentration: AX41 ≤EUs/μg
• Protein Length: 179 aa.
• Molecular Weight: 19.9 kDa
• Animal Origin Free: Yes

Specifications

• Accession Number: Q8IU54
• For Use With (Application): Control, ELISA, Gel Shift, Western Blot
• Formulation: 0.1% TFA with no preservative
• Gene ID (Entrez): 282618
• Molecular Weight (g/mol): 19.9 kDa
• Name: Human IL-29, AOF
• Quantity: 100 μg
• Source: E. coli
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Gene Alias: Cytokine Zcyto21; FNL1; IFN lambda1; IFNL1; IFN-lambda-1; IL29; IL-29; ILN; interferon lambda 1; Interferon lambda1; Interferon lambda-1; interferon, lambda 1; interferon-lambda-1; Interleukin; interleukin 29 (interferon, lambda 1); Interleukin-29; ZCYTO21
• Gene Symbol: IFNL1
• Specific Reactivity: Human
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Form: Lyophilized
• Purity or Quality Grade: >95%