Gibco™ Human IL-19, Animal-Free Recombinant Protein, PeproTech®

Product Code. 30019401

Brand: Gibco™ AF20019500UG

Description

Recombinant Protein

Recombinant Human IL-19 is a 35.8 kDa homodimer of two 154 amino acid chains. In solution, IL-19 exists predominantly as a non-disulfide-linked dimer.

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.

Specifications

• Accession Number: Q9UHD0
• For Use With (Application): Functional Assay
• Format: Lyophilized
• Formulation: protein with no preservative
• Gene ID (Entrez): 29949
• Molecular Weight (g/mol): 35.8 kDa
• Name: Human IL-19, Animal-Free
• Quantity: 500 μg
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: il 19; IL-10 C; IL19; IL-19; ILN; Interleukin; interleukin 19; Interleukin19; interleukin-19; MDA1; MDA-1; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein; NG0.1; ZMDA1
• Common Name: IL-19
• Biological Activity: Determined by its ability to stimulate the proliferation of HEK-Blue TM-IL-19 reporter cells
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.