eBioscience™ Mouse M-CSF, Recombinant Protein
Mouse Recombinant Protein
Brand: Affymetrix eBioscience 14-8983-80
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionMacrophage colony-stimulating factor (M-CSF or CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization.
M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. The secreted protein is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex.
|Store at less than or equal to -70°C.|
|Insect expressed C-terminal His-tagged Lys33-Pro187, accession number NM_001113530|
|Macrophage colony stimulating factor, monocyte colony stimulating factor|
|Sterile liquid; phosphate buffered saline with 1% BSA, pH 7.2 0.22μm filtered.|
|Less than 0.01ng/μg cytokine as determined by the LAL assay.|
|The ED50 of this protein, as determined by M-NFS-60 proliferation, is less than or equal to 10ng/mL. This corresponds to a specific activity of greater than or equal to 1 x 105 Units/mg.|