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Invitrogen™ eBioscience™ Human CD25, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand:  Invitrogen™ 34-8702-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15558826

  • £146.13 / 25µg


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Description

Description

The human soluble IL-2 receptor alpha chain (sIL-2Ra) is generated by proteolytic cleavage of the cell-surface bound receptor on activated T cells. The IL-2Ra (also known as CD25) is expressed by early progenitors of the T and B lineage, as well as by activated mature T and B lymphocytes. By itself, CD25 binds IL-2 with low affinity. However, association with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) results in formation of the high affinity IL-2R. CD25 plays a role in lymphocyte differentiation and activation/proliferation. sIL-2Ra has been detected in the serum of patients with autoimmune disease and leukemia. Reports have demonstrated that addition of sIL-2Ra can inhibit IL-2-mediated signaling and enhance Th17 responses.
Specifications

Specifications

Functional Assays
24.8kDa
SDS-PAGE and HPLC
25μg
Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.
Insect cells (amino acids Glu22- Gln240; Accession #: NP_000408.1)
The ED50 of this protein, as determined by increased proliferation of mouse CTLL-2 cells stimulated with 1ng/mL IL-2, is 0.5-1.5μg/mL.
Unlabeled
Yes
Lyophilized from 1X PBS.
CD25
>98%
Insect Cells
RUO
Less than 0.1ng/μg cytokine as determined by the LAL assay
Recombinant Protein, Carrier-Free
Human
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