eBioscience™ Mouse TPO, Recombinant Protein, Carrier-Free

Mouse Recombinant Protein

Overview
Brand: eBioscience™

Manufacturer Part Number: 34-8686-82

100UG Mouse Thrombopoietin (TPO) Recombinant Protein Carrier-Free

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15578816

Quantity Price
1 £ 865.5 / 100µg
Estimated Shipment date
from Supplier 08-12-2016
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Description and Specification

Specification

Conjugate Unlabeled
Cross Reactivity Mouse
For Use With (Application) Functional Assays
Formulation Lyophilized from 10mM Tris, pH 8.0
Molecular Weight 18.7
Name TPO
Purification Method SDS-PAGE and HPLC
Purity >98%
Quantity 100μg
Recombinant Yes
Source E. coli
Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.
Regulatory Status RUO
Structural Form E. coli (amino acids Glu22-Thr195; Accession # NP_001166976.1)
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay
Gene Symbol THPO, MPL ligand
Biological Activity The ED50 of this protein, as measured by proliferation of human MO7e cells, is less than or equal to 1.0ng/mL, which corresponds to a specific activity of at least 1.0 x 106 Units/mg.
Product Type Recombinant Protein, Carrier-Free

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.