Gibco™ Human IGF-II, Animal-Free Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Brand:  Gibco™ AF-100-12-10UG

Product Code. 17833313

Description

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.

Specifications

• Accession Number: P01344
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 7.5
• Quantity: 10 μg
• Storage Requirements: -20°C
• Endotoxin Concentration: <0.1 EU/μg
• Gene Symbol: IGF2
• Conjugate: Unconjugated
• Sequence: AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.

• For Use With (Application): Functional Assay
• Gene ID (Entrez): 3481
• Name: Human IGF-II, Animal-Free
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: AL033362; C11orf43; FLJ22066; FLJ44734; GRDF; H-IGF-2; IGF; Igf2; Igf-2; IGFII; Igf-II; Insulin like growth factor; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); Insulin-like growth factor II Ala-25 Del; insulin-like growth factor II isoform 2 variant 4 preprotein; insulin-like growth factor type 2; M6pr; Mpr; MSA; multiplication-stimulating activity; Multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; RNIGF2; Somatomedin-A; T3M-11-derived growth factor
• Specific Reactivity: Human
• Recombinant: Recombinant
• Form: Lyophilized