eBioscience™ Human IFN beta, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Overview
Brand: eBioscience™

Manufacturer Part Number: 34-8699-64

20UG Human IFN beta Recombinant Protein Carrier-Free

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15538826

Quantity Price
1 £ 146.13 / 20µg
Estimated Shipment date
from Supplier 28-02-2017
Add to basket


Description and Specification

Specification

For Use With (Application) Functional Assays
Molecular Weight 20kDa
Purification Method SDS-PAGE and HPLC
Regulatory Status RUO
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay
Biological Activity The ED50 of this protein, as measured by stimulation of human TF-1 cell proliferation, is less than or equal to 0.1ng/mL, which corresponds to a specific activity of at least 1 x 107 units/mg.
Formulation Lyophilized from 10mM sodium citrate, 100mM sodium chloride, and 10mM sucrose
Purity >95%
Quantity 20μg
Recombinant Yes
Source CHO Cells
Structural Form CHO cells (amino acids Met22-Asn187; Accession # AAC41702.1)
Validated Application FA
Conjugate Unlabeled
Cross Reactivity Human
Name IFN beta

Human interferon beta is a glycosylated member of the type I family of interferons, which also includes IFN alpha. Human IFN alpha and beta share 50% amino acid sequence homology and bind the IFN a/b receptor (IFNAR), which consists of two subunits IFNAR1 and IFNAR2, with different affinities. Binding of IFN to its receptor activates signal transduction, including the JAK/STAT and p38 MAPK pathways. Many studies have established IFN beta as a mediator of anti-viral, anti-proliferative, and anti-inflammatory functions, as well as an effective treatment for multiple sclerosis.