eBioscience™ Human IFN beta, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 34-8699-64

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15538826

Quantity Price
1 £ 146.13 / 20µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

For Use With (Application) Functional Assays
Molecular Weight 20kDa
Purification Method SDS-PAGE and HPLC
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay
Formulation Lyophilized from 10mM sodium citrate, 100mM sodium chloride, and 10mM sucrose
Regulatory Status RUO
Biological Activity The ED50 of this protein, as measured by stimulation of human TF-1 cell proliferation, is less than or equal to 0.1ng/mL, which corresponds to a specific activity of at least 1 x 107 units/mg.
Source CHO Cells
Structural Form CHO cells (amino acids Met22-Asn187; Accession # AAC41702.1)
Recombinant Yes
Validated Application FA
Cross Reactivity Human
Purity >95%
Quantity 20μg
Conjugate Unlabeled
Name IFN beta

Human interferon beta is a glycosylated member of the type I family of interferons, which also includes IFN alpha. Human IFN alpha and beta share 50% amino acid sequence homology and bind the IFN a/b receptor (IFNAR), which consists of two subunits IFNAR1 and IFNAR2, with different affinities. Binding of IFN to its receptor activates signal transduction, including the JAK/STAT and p38 MAPK pathways. Many studies have established IFN beta as a mediator of anti-viral, anti-proliferative, and anti-inflammatory functions, as well as an effective treatment for multiple sclerosis.