eBioscience™ Human IFN beta, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand: eBioscience™

Manufacturer Part Number: 34-8699-64

20UG Human IFN beta Recombinant Protein Carrier-Free

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Disclaimers: For Research Use Only.

Product Code. 15538826

Quantity Price
1 £222.70 / 20µg
Estimated Shipment date
from Supplier 28-10-2016
Add to basket

Description and Specification


Conjugate Unlabeled
Cross Reactivity Human
For Use With (Application) Functional Assays
Formulation Lyophilized from 10mM sodium citrate, 100mM sodium chloride, and 10mM sucrose
Molecular Weight 20kDa
Name IFN beta
Purification Method SDS-PAGE and HPLC
Purity >95%
Quantity 20μg
Recombinant Yes
Source CHO Cells
Regulatory Status RUO
Structural Form CHO cells (amino acids Met22-Asn187; Accession # AAC41702.1)
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay
Validated Application FA
Biological Activity The ED50 of this protein, as measured by stimulation of human TF-1 cell proliferation, is less than or equal to 0.1ng/mL, which corresponds to a specific activity of at least 1 x 107 units/mg.

Human interferon beta is a glycosylated member of the type I family of interferons, which also includes IFN alpha. Human IFN alpha and beta share 50% amino acid sequence homology and bind the IFN a/b receptor (IFNAR), which consists of two subunits IFNAR1 and IFNAR2, with different affinities. Binding of IFN to its receptor activates signal transduction, including the JAK/STAT and p38 MAPK pathways. Many studies have established IFN beta as a mediator of anti-viral, anti-proliferative, and anti-inflammatory functions, as well as an effective treatment for multiple sclerosis.